Studies on Capsules

Further electron microscopic studies on the expression of Escherichia coli group II capsules.

The de novo expression of Escherichia coli K1, K5, and K12 capsules was analyzed with immunoelectron microscopy in temperature upshift experiments, with upshift from 18 degrees C (capsule restrictive) to 37 degrees C (capsule permissive). Newly produced capsular polysaccharides appeared at the cell surface atop membrane adhesion sites (Bayer's junctions). After plasmolysis of the bacteria at an...

Effect of LoxOralTM and Lactose on In Vitro Dissolution Studies of Progesterone Sustained Release Capsules

Introduction: In vitro drug release and dissolution testing play an important role in pharmaceutical formulation development and quality control. Poorly soluble candidate molecules constitute a major challenge for the formulation development since the insufficient solubility causes problems for in vitro and in vivo assays, with consequent increased risk of attrition and costs (Di et al., 2012),...

Addison on the `supra-renal Capsules'*

ADULATION of Addison and Bright in Britain's medical circles resounds only slightly less loudly than Harveian songs of praise. These men carry a large share of legendary British medicine in their names. Of recent years Harvey's worthiness of such a role has been the subject of several studies; as a result he has, if possible, gained in stature. What of Addison? The question is prompted by the a...

Sandimmune Soft Gelatin Capsules

Self-exploding capsules

a Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ghent, Belgium. E-mail: [email protected] b Laboratory of Molecular Immunology, Department of Molecular Biomedical Research, Ghent University, Ghent, Belgium c Laboratory of General Biochemistry and Physical Pharmacy, Department of Pharmaceutics, Ghent University, Belgium d Department of Pharmaceutics, U...